Maximum androgen blockade
author: doctor Antonova A.Yu.
The maximum androgenic blockade is one of the ways to treat prostate cancer. This disease is a tumor that develops under the influence of male sex hormones - androgens (testosterone).
Most, namely 90-95% of testosterone is produced in the testicles, the rest - in the adrenal gland and adipose tissue. Thus, androgen blockade is the removal of male sex hormones in one way or another, and the maximum androgen blockade is a method of treatment, which consists in the combination of surgical or drug castration with the appointment of antiandrogens.
Who are luteinizing hormone agonists?
Surgical castration (orchiectomy) is an operation to remove male sex glands (testicles) under local anesthesia. The level of hormones drops a few hours after the operation. Drug castration - lowering the level of male sex hormones with the help of special medicines - luteinizing hormone agonists. To this end, use Buserelin, goserelin, tryptorelin, which are administered subcutaneously, as a rule, once in 28 days. When they are used on 3-5 days, there is a so-called "flash syndrome", that is, an increase in the testosterone level for a short period, but on days 21-28 its level is finally reduced. Side effects of these methods: osteoporosis - decreased bone density, gynecomastia (small enlargement of the mammary glands), erectile dysfunction (impotence), violation of sexual desire.
Since after the surgical or drug castration the body stops producing 90-95% of male hormones, then to reduce the production of the remaining 5-10%, the appointment of antiandrogens is necessary. Antiandrogens are drugs that compete with testosterone in the cells of the prostate gland, which leads to a decrease in tumor growth.
Steroid and nonsteroidal preparations
According to the chemical structure of the drugs are divided into steroid and non-steroid. Differently, non-steroidal anti-androgens do not lead to a decrease in the concentration of testosterone, which, when prescribed, remains at a normal or even slightly elevated level. Steroid include chloromadinone, cyproterone, megestrol. May cause such side effects as decreased sexual desire, gynecomastia, cardiovascular complications, disruption of the gastrointestinal tract (diarrhea, bloating, nausea, vomiting).
Nonsteroid - flutamide, bicalutamide (Casodex), nilutamide. Treatment with these drugs is not accompanied by a decrease in libido, general physical activity, since they do not reduce the concentration of testosterone. Of the side effects may be violations of the liver, gynecomastia, visual impairment, anemia.
Usually the maximum androgenic blockade is the standard method of treating prostate cancer with metastases, it is prescribed during the first 6 months of treatment for a quicker effect, afterwards antiandrogens can be canceled.
DAGenao: That's the problem with meds, they alleviate one problem and create many other problems. Why not try to solve the problem naturally through proper dieting?
David Johnson: NM BONE IMAGING WHOLE BODY results July 2020 (After 4- 90 day injections of Lupron) / COMPARISON: May 2019 Results No evidence of metastatic prostate cancer. (Before first injection of Lupron August 2019) Previously seen Scan small focus of radiotracer activity at the left posterior elements L5-S1 level is similar to previous. This is consistent with degenerative uptake. **There is degenerative-type uptake about the shoulders, acromioclavicular joints, sternoclavicular joints, spine, knees, ankles, feet and hips. There is no other new frank evidence of acute blastic metastatic activity. Physiologic uptake and excretion. Current age 60. I was told by Urologist the latest test results, which I am not buying. "Your tests are normal. They only show normal degenerative changes related to aging" Had HD Brachytherapy Nov 2019, finished 5 weeks HD radiation Mid January.
Roger Dodger: Be wary of hormone therapy. I had Lupron. It damaged my brain. Trouble with memory, thinking, vision, balance, etc etc etc. Five years later I am still struggling with a damaged brain. It doesn’t happen to everybody but it happened to me. Think twice! Good luck 🍀👍!
Jjgolfer331: I have prostate cancer and have a few hot spots on my hips. My original Urologist sent me to a second Urologist, and had that appointment a week ago. We discussed the options, which was surgery, followed by hormone therapy, or doing the hormone therapy and see where it goes, with option for surgery later. He discussed trial groups, but he told me I did not have a choice in which group I would be placed in...chemo or surgery plus...I decided on hormone therapy first, with option for surgery later if cancer shrinks or maintains.. My question is since I decided on the therapy is this: He is sending me to a third Urologist closer to where I live, so I am wondering, to take the pills, do I have to go to the Urologist's office each day to take the pill forms? He said I could have the shots done by my local Urologist, but he is only in the office in my area on Monday I am confused and have called the office of the second Urologist, but have not gotten any response...Has been a week and have not heard anything about an appointment with this third Urologist, which he said he would set up immediately. Can you give me some clarity on the hormone therapy, and tell me if the pill form has to done in the office, or can there be given a prescription so I can take at home? Appreciate any information you can give...I am on a limited income so traveling each day for therapy will put a stain on me, physically and mentally. I am turning 66 at the end of this month.
Russell Austin: Just seen a video which says hormonal therapy brings on heart attacks and strokes ! Anyone here been on HT for some time ?
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